(03-12-2020 03:49 PM)CrimsonPhantom Wrote:  We’ve Got The Vaccine, Says Pentagon-Funded Company

Quote: Canadian firm says it could make 10 million doses per month — if its innovative production method wins FDA approval.

A Canadian company says that it has produced a COVID-19 vaccine just 20 days after receiving the coronavirus’s genetic sequence, using a unique technology that they soon hope to submit for FDA approval.

Medicago CEO Bruce Clark said his company could produce as many as 10 million doses a month. If regulatory hurdles can be cleared, he said in a Thursday interview, the vaccine could start to become available in November.

An Israeli research lab has also claimed to have created a vaccine. But Clark says his company’s technique, which has already been proven effective in producing vaccines for seasonal flu, is more reliable and easier to scale.

“There are a couple of others who are claiming that they have — well, we will call them vaccine[s]” for COVID-19, he said. “But they’re different technologies. Some are RNA- or DNA-based vaccines that have not yet been proven in any indication yet, let alone this one. Hopefully, they’ll be successful.”

How did Clark’s team create one so quickly,? They use plants, not chicken eggs, as a bioreactor for growing vaccine proteins.

Traditional vaccine production requires eggs, a lot of them. Vaccine manufacturers inject the virus into the eggs, where it propagates. But using eggs is expensive, takes a long time, and is far from perfect. Mutations can yield vaccines that don’t match up to the virus they aim to shut down, Clark said

So Medicago doesn’t work with a live virus. Instead, it uses plants, a relatively new approach that has seen much advancement in the past decade. It inserts a genetic sequence into agrobacterium, a soil bacteria, which is taken up by plants — in this case, a close cousin to tobacco. The plant begins to produce the protein that can then be used as a vaccine. If the virus begins to mutate, as is expected for COVID-19, they can just update the production using new plants.

“That’s the difference between us” and egg-based methods, he said, ”we go directly to producing the vaccine or the antibody without having to propagate the virus.”

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