It is certainly something that would be cool if it actually came to fruition. For Cincinnati, I do not think it would be too hard.
1. Miami (OH)- alternate H/H or play it at Paul Brown yearly
2. MAC school #2- upper tier: either a H/H or a 2/1 with UC getting two home games. (like Toledo)
3. MAC school #3- lower tier: 2/1 or a 3/1 (like Akron)
4. B1G School #1- Upper tier: already have Nebraska, OSU and Michigan on future schedules. Could be a 2/1 at the B1G school with Cincinnati's home game at PBS
5. B1G School #2- Lower tier: a H/H with a school like Indiana, Purdue, Illinois, etc
6. Local Rival- Louisville, Pittsburgh, Va Tech, West Virginia, or any other former BE opponent.
7. Out of region P5 (or MWC) series with a MWC school, lower tier Big 12 or Pac 12 school (like Oregon State, Texas Tech, Fresno, Wyoming,etc)
8-12. Navy, Army, UConn, BYU, Boise State
That certainly looks better than the American conference slate....
Oh well, back to reality