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A thread to share positive news about Covid-19 Rx and vaccine developments
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smu89 Offline
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A thread to share positive news about Covid-19 Rx and vaccine developments
world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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07-27-2020 09:53 AM
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Hurricane Drummer Offline
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Post: #42
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 09:53 AM)smu89 Wrote:  world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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This is good news. Thanks for sharing.
07-27-2020 10:36 AM
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TIGERCITY Offline
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Post: #43
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 10:36 AM)Hurricane Drummer Wrote:  
(07-27-2020 09:53 AM)smu89 Wrote:  world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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This is good news. Thanks for sharing.

You can sign up to be one of those 30,000 at this site. They will need plenty of people who do not believe in wearing masks or social distancing or that Covid-19 is a hoax --- so hoping some of those morons here will sign up.

https://www.nih.gov/news-events/news-rel...-19-begins
(This post was last modified: 07-27-2020 10:52 AM by TIGERCITY.)
07-27-2020 10:50 AM
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Tiger1983 Offline
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Post: #44
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 09:53 AM)smu89 Wrote:  world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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There is no substitute for human trials. Without human volunteers for testing, no vaccines would be possible in a country like the USA. I commend the volunteers willing to take the risks on behalf of older folks like me and for the risk adverse.
07-27-2020 11:03 AM
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CoastalJuan Offline
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Post: #45
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
We just dosed our first patient on the Moderna Phase III trial!!

Moderna Announces First Participants Dosed in Phase III Study

"Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the Phase 3 study of its mRNA vaccine candidate (mRNA-1273) against COVID-19 has begun dosing participants. "
07-27-2020 11:07 AM
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smu89 Offline
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Post: #46
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 11:03 AM)Tiger1983 Wrote:  
(07-27-2020 09:53 AM)smu89 Wrote:  world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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There is no substitute for human trials. Without human volunteers for testing, no vaccines would be possible in a country like the USA. I commend the volunteers willing to take the risks on behalf of older folks like me and for the risk adverse.
Stay safe

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07-27-2020 07:21 PM
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Tiger1983 Offline
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Post: #47
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 07:21 PM)smu89 Wrote:  
(07-27-2020 11:03 AM)Tiger1983 Wrote:  
(07-27-2020 09:53 AM)smu89 Wrote:  world’s biggest coronavirus vaccine study begins, a U.S. trial that will include 30,000 people to see if the shots really work

https://www.cnbc.com/2020/07/27/the-worl...-work.html

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There is no substitute for human trials. Without human volunteers for testing, no vaccines would be possible in a country like the USA. I commend the volunteers willing to take the risks on behalf of older folks like me and for the risk adverse.
Stay safe

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You also. 04-cheers
07-28-2020 01:12 PM
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TIGERCITY Offline
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Post: #48
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
A study that shows that 35% of blood donors that have never been exposed to covid-19 still show reactive immune cells to covid-19's spike protein (used to infect the cell.) The covid19 spike has a very close relationship to other endemic human coronaviruses spike proteins and possibly the source of this immunity. 35% is a lot and probably explains the asymptomatics. Possibly young children. Linked below -

https://www.nature.com/articles/s41586-020-2598-9
(This post was last modified: 07-29-2020 11:21 AM by TIGERCITY.)
07-29-2020 11:18 AM
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Tiger1983 Offline
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RE: A thread to share positive news about Covid-19 Rx and vaccine developments
08-01-2020 07:47 PM
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smu89 Offline
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Post: #50
A thread to share positive news about Covid-19 Rx and vaccine developments
https://www.fox4news.com/news/texas-am-t...us-vaccine

Texas A&M University has been selected to help lead the effort producing mass quantities of a potential coronavirus vaccine.
If it proves successful, a vaccine being developed by a little-known company called Novavax could be manufactured at the university to help get as many doses to the public as possible. But, Novavax has never before produced a vaccine for public use.

The Trump administration awarded the University Systems Center for Innovation in Advanced Development and Manufacturing a $265 million contract to ramp up to mass manufacture a potential vaccine.

“Part of that will go for expansion and capabilities of that particular system, but most will go towards the producing of the vaccine itself,” said John Sharp, Chancellor, Texas A&M University Systems.


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08-04-2020 10:41 AM
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Atlanta Offline
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Post: #51
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(07-27-2020 11:07 AM)CoastalJuan Wrote:  We just dosed our first patient on the Moderna Phase III trial!!

Moderna Announces First Participants Dosed in Phase III Study

"Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the Phase 3 study of its mRNA vaccine candidate (mRNA-1273) against COVID-19 has begun dosing participants. "

First dosing was very negative. Many experienced pain, fever & swelling. Bad enough that many were taken off the drug. And BTW, this drug alters RNA which has been judged unethical in several previous drug trials. Not so good news.
08-04-2020 11:14 AM
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smu89 Offline
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Post: #52
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(08-04-2020 11:14 AM)Atlanta Wrote:  
(07-27-2020 11:07 AM)CoastalJuan Wrote:  We just dosed our first patient on the Moderna Phase III trial!!

Moderna Announces First Participants Dosed in Phase III Study

"Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the Phase 3 study of its mRNA vaccine candidate (mRNA-1273) against COVID-19 has begun dosing participants. "

First dosing was very negative. Many experienced pain, fever & swelling. Bad enough that many were taken off the drug. And BTW, this drug alters RNA which has been judged unethical in several previous drug trials. Not so good news.
Seems this is expected?

https://www.statnews.com/2020/07/27/covi...not-alarm/

experts say the data so far suggest one important possibility: The vaccines may carry a bit of a kick.
In vaccine parlance, they appear to be “reactogenic,” meaning they have induced short-term discomfort in a percentage of the people who have received them in clinical trials. This kind of discomfort includes headache, sore arms, fatigue, chills, and fever.
As long as the side effects of eventual Covid-19 vaccines are transient and not severe, these would not be sources of alarm — in fact, they may be signals of an immune system lurching into gear. It’s a simple fact that some vaccines are more unpleasant to take than others. Think about the pain of a tetanus shot, for instance.


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08-04-2020 10:31 PM
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Atlanta Offline
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Post: #53
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(08-04-2020 10:31 PM)smu89 Wrote:  
(08-04-2020 11:14 AM)Atlanta Wrote:  
(07-27-2020 11:07 AM)CoastalJuan Wrote:  We just dosed our first patient on the Moderna Phase III trial!!

Moderna Announces First Participants Dosed in Phase III Study

"Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the Phase 3 study of its mRNA vaccine candidate (mRNA-1273) against COVID-19 has begun dosing participants. "

First dosing was very negative. Many experienced pain, fever & swelling. Bad enough that many were taken off the drug. And BTW, this drug alters RNA which has been judged unethical in several previous drug trials. Not so good news.
Seems this is expected?

https://www.statnews.com/2020/07/27/covi...not-alarm/

experts say the data so far suggest one important possibility: The vaccines may carry a bit of a kick.
In vaccine parlance, they appear to be “reactogenic,” meaning they have induced short-term discomfort in a percentage of the people who have received them in clinical trials. This kind of discomfort includes headache, sore arms, fatigue, chills, and fever.
As long as the side effects of eventual Covid-19 vaccines are transient and not severe, these would not be sources of alarm — in fact, they may be signals of an immune system lurching into gear. It’s a simple fact that some vaccines are more unpleasant to take than others. Think about the pain of a tetanus shot, for instance.


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The biggest issue with the Moderna vac candidate, aside from apparent rather severe reactions in stage 3 trials (enough to remove a substantial number from the trial) is that it permanently alters your RNA. Such approach has never been allowed & carries ethics & safety concerns. Should add for context, I am far from anti-vaccine, taking, benefiting from a variety of vaccines over my lifetime. But I am quite uncomfortable with the idea of altered RNA.
(This post was last modified: 08-05-2020 06:58 AM by Atlanta.)
08-05-2020 06:53 AM
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Tiger1983 Offline
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Post: #54
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Designer antibodies could battle COVID-19 before vaccines arrive

https://www.sciencemag.org/news/2020/08/...nes-arrive
08-05-2020 03:00 PM
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TIGERCITY Offline
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Post: #55
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(08-05-2020 03:00 PM)Tiger1983 Wrote:  Designer antibodies could battle COVID-19 before vaccines arrive

https://www.sciencemag.org/news/2020/08/...nes-arrive

Thanks, an interesting note that I read elsewhere is that your body normally responds with a number of different types of antibodies. Using one antibody here runs some risk of allowing any latent, unaffected, mutation to now take advantage and proliferate. Using two different antibodies makes this much less likely. They're using two different monoclonal antibodies here for that reason.
08-05-2020 06:45 PM
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TIGERCITY Offline
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Post: #56
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
The Novavax vaccine passed Phase 1 in human trials with excellent results. No adverse reactions except for things like soreness around the shot. *Created an immune response 4 times greater than seen in your typical covid-19 convalescent patient.* It's really looking good on the vaccine front --- the candidates are really stacking up now:-)

https://www.medrxiv.org/content/10.1101/...20168435v1

A blog post from the very readable Derek Lowe -

https://blogs.sciencemag.org/pipeline/ar...om-novavax
(This post was last modified: 08-06-2020 05:40 PM by TIGERCITY.)
08-06-2020 05:32 PM
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smu89 Offline
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Post: #57
A thread to share positive news about Covid-19 Rx and vaccine developments
https://www.realclearpolitics.com/articl...43875.html

In countries such as Great Britain and the United States, where the “Fauci-Hahn Strategy” was followed, there was a much higher death rate and an ever-increasing number of cases. COVID patients in the U.S. would continue to be quarantined at home and left untreated until they developed shortness of breath. Then they would be admitted to the hospital and given hydroxychloroquine outside the narrow window for the drug’s maximum effectiveness.
In further contrast, countries that started out with the “Fauci-Hahn Doctrine” and then later shifted their policy towards aggressive outpatient hydroxychloroquine use, after a brief lag period also saw a stunning rapid reduction in COVID mortality and hospital admissions.


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08-07-2020 03:57 PM
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smu89 Offline
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Post: #58
A thread to share positive news about Covid-19 Rx and vaccine developments
https://www.technocracy.news/aaps-fda-de...ths-daily/

20,000 more Americans have died while the FDA has delayed since July 1 a new emergency use approval for outpatient use of hydroxychloroquine (HCQ) for COVID-19.
On July, 1 Henry Ford Hospital physicians and researchers in Detroit filed an urgent request to FDA Commissioner Dr. Stephen Hahn for a new outpatient Emergency Use Authorization (EUA) for FDA approval of HCQ to be used in early treatment for COVID-19. Baylor Scott & White Heart and Vascular Institute in Dallas, issued an urgent appeal supporting the Henry Ford EUA application, based on their clinical study of prophylactic use of HCQ in their own medical workers. Baylor cardiologists emphasized there were no adverse cardiac outcomes in their own or the Ford study.
Henry Ford’s new clinical trial found an impressive 51% reduction in deaths if HCQ was begun within 24 hours of admission to hospital. An outpatient primary care study by Dr. Vladimir Zelenko, using HCQ, azithromycin and zinc given within less than 7 days of COVID-19 symptoms, showed approximately 80% decrease in deaths, and less than 1% of his patients needed to be admitted to hospital. These U.S. early intervention studies extraordinary results show how many lives can be saved with early HCQ treatment.
If the FDA had acted quickly on the Henry Ford and Baylor approval request for HCQ, we can reasonably consider that 16,000 lives could have been saved since July 1.
EUA applications do not have to take long to approve, when well documented rationale and supporting research is presented as Henry Ford team and Baylor cardiologists did.
HCQ is already an FDA-approved drug, unlike remdesivir, which had almost an immediate compassionate use authorization granted that has now been expanded for early use despite severe side effects. The former director of the FDA subagency BARDA, Rick Bright, Ph.D., submitted an EUA for HCQ approval for hospital use at 11:30 pm on March 28, 2020. Dr. Hahn’s approval was granted a little after midnight, March 29, 2020. Approval in about 30 minutes.
We have been waiting almost 30 days for Dr. Hahn to issue approval of the Henry Ford EUA application for outpatient use. Dr. Hahn has stated that we need more data. Henry Ford and Baylor doctors have already provided research documentation stronger than in Rick Bright’s March application, and included current COVID-19 studies from the U.S. and other countries.What amount of “data” will ever satisfy Dr. Hahn?


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08-08-2020 05:09 PM
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TIGERCITY Offline
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Post: #59
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Good news on transmission from children. This is a peer-reviewed study a 23 Greek families with SARS Co V2 transmission within families. 109 individuals, 43 or children 66 for adults. There was evidence of adult to adult transmission an adult to child transmission. * There is no evidence of child to adult transmission or child to child transmission.*

https://onlinelibrary.wiley.com/doi/abs/.../jmv.26394
08-08-2020 06:26 PM
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smu89 Offline
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A thread to share positive news about Covid-19 Rx and vaccine developments
https://pjmedia.com/news-and-politics/ma...fe-n766872

New York City councilman, says he nearly died of COVID-19 earlier this year, but hydroxychloroquine saved his life.

“I couldn’t breathe, very weak, couldn’t get out of bed. My doctor prescribed it. My pharmacy had it. Took it that day and within two to three days I was able to breathe,” Vallone told The New York Post. “Within a week I was back on my feet.”

“We were in panic mode when I went down because I didn’t have a lot of immune response,” he added. “I needed something to stay alive.”

That something was hydroxychloroquine. Vallone said, it “worked for me.”
Paul Vallone wasn’t the only one who became a believer in the anti-malaria drug’s effectiveness in treating COVID. His brother Peter, a former city councilman who currently serves as a civil court judge in Queens, couldn’t deny the drug worked after seeing how it helped his brother.

Peter Vallone has a theory why there’s resistance to accept the drug’s potential.
“I guess all those doctors who are prescribing it are right,” he said. “This drug is already on the market and the patent is up so it’s cheap. A new drug won’t be. So big money does not want this drug to be used. Always follow the money.”


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