Hello There, Guest! (LoginRegister)

Post Reply 
A thread to share positive news about Covid-19 Rx and vaccine developments
Author Message
CoastalJuan Offline
Business Drunk
*

Posts: 4,184
Joined: Sep 2014
Reputation: 190
I Root For: ECU
Location: Right near da beeech
Post: #261
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-18-2020 10:22 AM)Tiger1983 Wrote:  
(11-18-2020 10:19 AM)BearcatMan Wrote:  
(11-18-2020 10:16 AM)TIGERCITY Wrote:  Maybe talking out of my ass here since I have no idea what infrastructure or expertise are required to produce these 95% effective vaccines -- but if possible, I would like to see the president use his natural emergency powers and require Pfizer, Madonna, or any other highly effective vaccine that comes up be produced by all other companies that can effectively do it. Give them a cut. Or use the second stimulus money they're talking about and give interested parties a cut there. Get rid of this thing sooner likely does more than the stimulus money ever could.

The Defense Production Act was already used to create more PPE for frontline Healthcare Workers, so it could be done relatively easily. Without getting too political, I just hope the current President can set aside differences and pettiness to roll that plan out immediately should the FDA approve these options.

Without getting too political, I just hope all Governors set aside their animus against political opponents and stubborn pride and request the vaccine.

I don't think there will be any states that turn down any of the vaccines. I'm not even sure they will have to formally make a request. It's now public information that the US, at the country level, has already ordered a bunch, and other large countries are already putting in orders.

UK scrambles to buy 5m doses of Covid breakthrough vaccine

"UK officials have scrambled to secure 5m doses of a breakthrough coronavirus vaccine within four hours of early results, amid fears that Britain had missed out on supplies.

Interim findings from the US biotech firm Moderna – whose trials included high-risk and elderly people – suggested its vaccine was 95% effective. It is more expensive than the Pfizer/BioNTech version announced last week but can potentially be stored and transported more easily.

Meanwhile, the US secured 100m Moderna doses, with an option to buy 400m more, while the European commission has a “potential purchase agreement” for 80m-160m doses. Japan, Canada, Switzerland, Qatar and Israel also secured shots.

UK ministers remain hopeful that a vaccine developed by Oxford University and AstraZeneca could be available soon – even by Christmas – with results of that trial reported to be imminent."
11-18-2020 10:32 AM
Find all posts by this user Quote this message in a reply
BearcatMan Offline
Kicking Connoisseur/Occasional Man Crush
*

Posts: 16,713
Joined: Jan 2009
Reputation: 315
I Root For: Cincinnati
Location:
Post: #262
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-18-2020 10:25 AM)TIGERCITY Wrote:  Bearcatman, first these vaccines do not "produce virus" inside your body. Second, the vaccine itself has caused no adverse reactions. In fact, the vaccine is cleared after a couple of weeks leaving only your boosted immune response. No one who knows what long-term effects some people may have to that - but they'll be long-term and no one's willing to wait for 2 years for that (although phase 4 trials will continue that long)

messengerRNA (or mRNA, the basis of this vaccine), in lay term, is used to DNA instructions on how to produces proteins/cells/etc. In the case of this vaccine, the mRNA being developed exclusively produces the viral protein strains when encoded...now most viral proteins are effectively "dead" and do not have the ability to self-replicate, so this, in theory, is perfect fine, all I'm saying is we're operating in "theory" territory, and as one of my senior faculty always says, "Life always has a way of making 'in theory' irrelevant."

All of this is to say that I'm not at all skeptical with the immediate results and will absolutely be in line should these get approval, just that we simply do not know the long term effects of having synthetic mRNA activated proteins in our bodies, and more specifically, if giving the "instructions" to our DNA will allow them to continuously produce these proteins as there is no "off-switch" outside of our immune response and the expectation that our body's cells will know to stop producing these proteins.
11-18-2020 10:33 AM
Find all posts by this user Quote this message in a reply
CoastalJuan Offline
Business Drunk
*

Posts: 4,184
Joined: Sep 2014
Reputation: 190
I Root For: ECU
Location: Right near da beeech
Post: #263
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-18-2020 10:25 AM)TIGERCITY Wrote:  Bearcatman, first these vaccines do not "produce virus" inside your body. Second, the vaccine itself has caused no adverse reactions. In fact, the vaccine is cleared after a couple of weeks leaving only your boosted immune response. No one who knows what long-term effects some people may have to that - but they'll be long-term and no one's willing to wait for 2 years for that (although phase 4 trials will continue that long)

The mRNA vaccines do technically prompt your body produce virus protein. That said, the proteins don't have the ability to infect your cells. It's similar to how we inject dead flu cells to develop flu immunity before the body is faced with active viral cells.
11-18-2020 10:43 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #264
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
What do you mean "there's no off switch?" Vaccine contains only a finite amount of mRNA. There's no ongoing replication in your body. When the vaccine is cleared it's cleared and that's the end of it. Honestly I don't think you know what you're talkin about.
11-18-2020 10:44 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #265
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-18-2020 10:53 AM)TIGERCITY Wrote:  I
(11-18-2020 10:43 AM)CoastalJuan Wrote:  
(11-18-2020 10:25 AM)TIGERCITY Wrote:  Bearcatman, first these vaccines do not "produce virus" inside your body. Second, the vaccine itself has caused no adverse reactions. In fact, the vaccine is cleared after a couple of weeks leaving only your boosted immune response. No one who knows what long-term effects some people may have to that - but they'll be long-term and no one's willing to wait for 2 years for that (although phase 4 trials will continue that long)

The mRNA vaccines do technically prompt your body produce virus protein. That said, the proteins don't have the ability to infect your cells. It's similar to how we inject dead flu cells to develop flu immunity before the body is faced with active viral cells.

Yep, a small portion of mRNA that codes for the receptor binding domain on the spike protein of the virus (the part that actually sticks to your cell when being infected) - that small portion of mRNA that does nothing by itself is encased in a nano lipid particle (think small small small oil droplet). Since our cells are made of lipid on the outside - imagine oil droplets in water and how they interact with each other. So the nanoparticles fuse with our cell membranes and that tiny portion of mRNA is introduced into the cell where it's turned into binding domain proteins, not replicated, by our cells ribosomes. Since it's recognized as foreign - specialized molecules called MHC will grab it and displayed on the cell surface. From there our immune system takes over, sees the Protein that's been produced, and start producing antibodies against it. That is a nutshell is how it works.
11-18-2020 11:22 AM
Find all posts by this user Quote this message in a reply
BearcatMan Offline
Kicking Connoisseur/Occasional Man Crush
*

Posts: 16,713
Joined: Jan 2009
Reputation: 315
I Root For: Cincinnati
Location:
Post: #266
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-18-2020 10:44 AM)TIGERCITY Wrote:  What do you mean "there's no off switch?" Vaccine contains only a finite amount of mRNA. There's no ongoing replication in your body. When the vaccine is cleared it's cleared and that's the end of it. Honestly I don't think you know what you're talkin about.

I'm a Civil Engineer, all that I said is paraphrased from a couple of conversations I've had since these announcements with a member of faculty in our Bioengineering Department that works specifically on cellular response research. The "no off-switch" comment is probably oversimplified, but essentially what he is worried about is that a synthetic mRNA may or may not propagate in the body past the immuno-response, which would mean that we may be giving our cells a permanent means with which to replicate, again, some terminology may be messed up, as biology was never my strong suit (I could talk till I'm blue in the face about materials science and structural metallurgy). To be clear, he's not against them, and will get them same as me when they're available, he is just skeptical about the long-term impact.
11-18-2020 11:24 AM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #267
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Immunization against COVID-19 could last years, new study claims

https://nypost.com/2020/11/17/immunizati...dy-claims/

Johnson and Johnson expects single shot vaccine ready for approval by February 2021.

https://www.foxnews.com/health/johnson-j...feb-report
(This post was last modified: 11-18-2020 04:28 PM by Tiger1983.)
11-18-2020 02:06 PM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #268
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Headline from WSJ:

"Oxford, AstraZeneca Coronavirus Vaccine’s Strong Response in Elderly Confirmed in Review
Vaccine’s overall efficacy is still not known, but peer-reviewed data shows strong immune response in older adults"

https://www.wsj.com/articles/oxford-astr...1605783756
11-19-2020 09:07 AM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #269
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Scientists at St. Jude Children’s Research Hospital have identified two proteins that may be linked to the inflammatory storm that causes lung damage, organ failure and often death in COVID patients.

Drugs already approved for other diseases, including Krohn’s disease, could be repurposed to fight the condition.

https://dailymemphian.com/section/corona...k-to-covid
(This post was last modified: 11-19-2020 10:02 AM by Tiger1983.)
11-19-2020 10:01 AM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #270
RE: A thread to share positive news about Covid-19 Rx and vaccine developments


FWIW, I read Fauci state first batch to high priority groups should be given by end of December.
(This post was last modified: 11-20-2020 09:19 AM by Tiger1983.)
11-20-2020 08:56 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #271
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-20-2020 08:56 AM)Tiger1983 Wrote:  

FWIW, I read Fauci state first batch to high priority groups should be given by end of December.


The FDA is not scheduled to discuss the EUA until sometime in the first half of December. Why not this week? I genuinely do not get it.
https://www.cnbc.com/2020/11/20/covid-19...ation.html
11-20-2020 09:26 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #272
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
FDA's press release. They will meet December 10th.

https://www.fda.gov/news-events/press-an...19-vaccine
11-21-2020 10:51 AM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #273
RE: A thread to share positive news about Covid-19 Rx and vaccine developments

(This post was last modified: 11-21-2020 10:36 PM by Tiger1983.)
11-21-2020 10:35 PM
Find all posts by this user Quote this message in a reply
Memphis Yankee Offline
Heisman
*

Posts: 5,922
Joined: Oct 2017
Reputation: 310
I Root For: Memphis
Location: Las Vegas
Post: #274
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-21-2020 10:35 PM)Tiger1983 Wrote:  

Vote Trump out of office. He only had a vaccine made five times faster than any other vaccine in the history of mankind. Trump is a loser.
11-22-2020 12:38 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #275
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
Astrazeneca's phase 3 trials are published. This is different than mRNA vaccines. Here a chimpanzee adenovirus is used as the vector delivering the viruses spike protein RNA. There were two types of dosing here. High-dose followed by high dose and a low dose followed by a high dose. The last (low-high) was 90% effective so I'm sure that's what they'll use --- plus it allows more people to be vaccinated (not as much vaccine used). Also they tested for asymptomatic infections PCR testing the participants each week. Pfizer and moderna did not do this. Here, in the vaccinated arm there were 30 total infections, 27 in high-high dose and 3 in low-high dose - zero severe infections and zero infections requiring hospitalization. We have another winner :-)

https://www.astrazeneca.com/content/astr...22hlr.html
11-23-2020 08:26 AM
Find all posts by this user Quote this message in a reply
goodknightfl Offline
Hall of Famer
*

Posts: 17,870
Joined: Feb 2004
Reputation: 292
I Root For:
Location:
Post: #276
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-20-2020 09:26 AM)TIGERCITY Wrote:  
(11-20-2020 08:56 AM)Tiger1983 Wrote:  
The FDA is not scheduled to discuss the EUA until sometime in the first half of December. Why not this week? I genuinely do not get it.

They need time to do Thanksgiving dinner with family n friends. The Black Friday sales.
11-23-2020 08:35 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #277
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-23-2020 08:35 AM)goodknightfl Wrote:  
(11-20-2020 09:26 AM)TIGERCITY Wrote:  
(11-20-2020 08:56 AM)Tiger1983 Wrote:  
The FDA is not scheduled to discuss the EUA until sometime in the first half of December. Why not this week? I genuinely do not get it.

They need time to do Thanksgiving dinner with family n friends. The Black Friday sales.

Actually I regret posting that gripe. It's my understanding they have thousands of pages of dense, highly technical reading. Since these vaccines will likely be given to billions of people - it's best to get it right on the front end.
11-23-2020 08:42 AM
Find all posts by this user Quote this message in a reply
TIGERCITY Offline
Hall of Famer
*

Posts: 16,680
Joined: Feb 2009
Reputation: 380
I Root For: Memphis
Location:
Post: #278
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-23-2020 08:26 AM)TIGERCITY Wrote:  Astrazeneca's phase 3 trials are published. This is different than mRNA vaccines. Here a chimpanzee adenovirus is used as the vector delivering the viruses spike protein RNA. There were two types of dosing here. High-dose followed by high dose and a low dose followed by a high dose. The last (low-high) was 90% effective so I'm sure that's what they'll use --- plus it allows more people to be vaccinated (not as much vaccine used). Also they tested for asymptomatic infections PCR testing the participants each week. Pfizer and moderna did not do this. Here, in the vaccinated arm there were 30 total infections, 27 in high-high dose and 3 in low-high dose - zero severe infections and zero infections requiring hospitalization. We have another winner :-)

https://www.astrazeneca.com/content/astr...22hlr.html

Interesting also that while they tested for asymptomatic the only found three infections in the low high dose.
11-23-2020 08:44 AM
Find all posts by this user Quote this message in a reply
Tiger1983 Offline
BBA
*

Posts: 29,090
Joined: Apr 2006
Reputation: 1099
I Root For: Tigers - GTG!
Location: Outside Belle Meade

DonatorsDonatorsDonators
Post: #279
RE: A thread to share positive news about Covid-19 Rx and vaccine developments
(11-23-2020 08:44 AM)TIGERCITY Wrote:  
(11-23-2020 08:26 AM)TIGERCITY Wrote:  Astrazeneca's phase 3 trials are published. This is different than mRNA vaccines. Here a chimpanzee adenovirus is used as the vector delivering the viruses spike protein RNA. There were two types of dosing here. High-dose followed by high dose and a low dose followed by a high dose. The last (low-high) was 90% effective so I'm sure that's what they'll use --- plus it allows more people to be vaccinated (not as much vaccine used). Also they tested for asymptomatic infections PCR testing the participants each week. Pfizer and moderna did not do this. Here, in the vaccinated arm there were 30 total infections, 27 in high-high dose and 3 in low-high dose - zero severe infections and zero infections requiring hospitalization. We have another winner :-)

https://www.astrazeneca.com/content/astr...22hlr.html


Interesting also that while they tested for asymptomatic the only found three infections in the low high dose.

It should be ready by around the end of the year, pending regulatory approval. The availability in the USA, however, will likely take longer due to need to alter trial for half dose/full dose method.

Our British cousins developed the shot.

Here are some additional facts per the WSJ:

1. Half dose followed by a full dose = 90% effective while two full doses were 62% effective.
2. Distribution does not require subfreezing temps
3. Astrazeneca does not intend to make a profit during the pandemic
4. Cost is about $3 to $5 per shot
5. They intend to distribute to developing countries
6. Manufacturing is a global effort

https://www.wsj.com/articles/astrazeneca..._lead_pos1

As an aside, the better efficacy of the low dose/high dose over high dose/high dose is counterintuitive. It is a reminder that common sense (e.g., source masking is very effective at preventing spread) cannot assumed to be correct. To the best of my knowledge, there is no randomized, controlled study finding source mask use beneficial.

However, I wish to emphasize I wear a KN-95 mask in appropriate situations because the weight of evidence to date supports its use and there is little risk assuming proper handling.
(This post was last modified: 11-23-2020 09:42 AM by Tiger1983.)
11-23-2020 09:09 AM
Find all posts by this user Quote this message in a reply
CoastalJuan Offline
Business Drunk
*

Posts: 4,184
Joined: Sep 2014
Reputation: 190
I Root For: ECU
Location: Right near da beeech
Post: #280
A thread to share positive news about Covid-19 Rx and vaccine developments
(11-23-2020 09:09 AM)Tiger1983 Wrote:  
(11-23-2020 08:44 AM)TIGERCITY Wrote:  
(11-23-2020 08:26 AM)TIGERCITY Wrote:  Astrazeneca's phase 3 trials are published. This is different than mRNA vaccines. Here a chimpanzee adenovirus is used as the vector delivering the viruses spike protein RNA. There were two types of dosing here. High-dose followed by high dose and a low dose followed by a high dose. The last (low-high) was 90% effective so I'm sure that's what they'll use --- plus it allows more people to be vaccinated (not as much vaccine used). Also they tested for asymptomatic infections PCR testing the participants each week. Pfizer and moderna did not do this. Here, in the vaccinated arm there were 30 total infections, 27 in high-high dose and 3 in low-high dose - zero severe infections and zero infections requiring hospitalization. We have another winner :-)

https://www.astrazeneca.com/content/astr...22hlr.html


Interesting also that while they tested for asymptomatic the only found three infections in the low high dose.

It should be ready by around the end of the year, pending regulatory approval.

Our British cousins developed the shot.


We’re the CRO on that one too. In on two out of three so far!


Sent from my iPhone using Tapatalk
11-23-2020 09:28 AM
Find all posts by this user Quote this message in a reply
Post Reply 




User(s) browsing this thread: 1 Guest(s)


Copyright © 2002-2020 Collegiate Sports Nation Bulletin Board System (CSNbbs), All Rights Reserved.
CSNbbs is an independent fan site and is in no way affiliated to the NCAA or any of the schools and conferences it represents.
This site monetizes links. FTC Disclosure.
We allow third-party companies to serve ads and/or collect certain anonymous information when you visit our web site. These companies may use non-personally identifiable information (e.g., click stream information, browser type, time and date, subject of advertisements clicked or scrolled over) during your visits to this and other Web sites in order to provide advertisements about goods and services likely to be of greater interest to you. These companies typically use a cookie or third party web beacon to collect this information. To learn more about this behavioral advertising practice or to opt-out of this type of advertising, you can visit http://www.networkadvertising.org.
Powered By MyBB, © 2002-2020 MyBB Group.