(11-16-2020 07:57 AM)TIGERCITY Wrote:  And here's the press release of Moderna's phase 3 interim results. Estimated "point efficacy" of 94.5. There were 95 cases of covid-19 in the study. 90 were in the placebo arm 5 in the vaccinated arm. 11 of the cases were "severe" *all* in the placebo arm.

https://investors.modernatx.com/news-rel...y-efficacy

Boom! We're the CRO on that one.

(11-10-2020 10:41 AM)TIGERCITY Wrote:  Read that one of the benefits of this new technology for human vaccines (mRNA vaccines) is that if the virus does mutate in a meaningful way then the mRNA vaccine can be changed to match that mutation.

In addition, Moderna, also in Phase 3 trials with their own MRna vaccine, expect an interim report on the results this month. I wouldn't be surprised if we have multiple vaccines available by the end of the year :)

Not sure permanently altering you're RNA is a good long term solution. Too much unknown on how it would affect immunity for yet to be discovered pathogens.

(11-16-2020 08:04 AM)Atlanta Wrote:  

(11-10-2020 10:41 AM)TIGERCITY Wrote:  Read that one of the benefits of this new technology for human vaccines (mRNA vaccines) is that if the virus does mutate in a meaningful way then the mRNA vaccine can be changed to match that mutation.

In addition, Moderna, also in Phase 3 trials with their own MRna vaccine, expect an interim report on the results this month. I wouldn't be surprised if we have multiple vaccines available by the end of the year :)

Not sure permanently altering you're RNA is a good long term solution. Too much unknown on how it would affect immunity for yet to be discovered pathogens.

mRNA vaccines don't alter your RNA, but I agree that altering your genetic makeup probably wouldn't be a good idea.

Atlanta - there are plenty of sources on the internet. When you say "permanently alter your RNA" it sounds like you totally misunderstand how this (and your biology) works.

(11-16-2020 08:40 AM)CoastalJuan Wrote:  

(11-16-2020 08:04 AM)Atlanta Wrote:  

(11-10-2020 10:41 AM)TIGERCITY Wrote:  Read that one of the benefits of this new technology for human vaccines (mRNA vaccines) is that if the virus does mutate in a meaningful way then the mRNA vaccine can be changed to match that mutation.

In addition, Moderna, also in Phase 3 trials with their own MRna vaccine, expect an interim report on the results this month. I wouldn't be surprised if we have multiple vaccines available by the end of the year :)

Not sure permanently altering you're RNA is a good long term solution. Too much unknown on how it would affect immunity for yet to be discovered pathogens.

mRNA vaccines don't alter your RNA, but I agree that altering your genetic makeup probably wouldn't be a good idea.

mRNA vaccines do not alter your DNA. These vaccines take a piece of the viruses RNA that codes for a portion of the spike protein used to enter your cells. Your sales then make copies of that portion of the spike protein (no active virus) and that is displayed on the surface of your cells. Immune cells then come by and read that and begin making antibodies. That's it.

(11-16-2020 08:45 AM)TIGERCITY Wrote:  

(11-16-2020 08:40 AM)CoastalJuan Wrote:  

(11-16-2020 08:04 AM)Atlanta Wrote:  

(11-10-2020 10:41 AM)TIGERCITY Wrote:  Read that one of the benefits of this new technology for human vaccines (mRNA vaccines) is that if the virus does mutate in a meaningful way then the mRNA vaccine can be changed to match that mutation.

In addition, Moderna, also in Phase 3 trials with their own MRna vaccine, expect an interim report on the results this month. I wouldn't be surprised if we have multiple vaccines available by the end of the year :)

Not sure permanently altering you're RNA is a good long term solution. Too much unknown on how it would affect immunity for yet to be discovered pathogens.

mRNA vaccines don't alter your RNA, but I agree that altering your genetic makeup probably wouldn't be a good idea.

mRNA vaccines do not alter your DNA. These vaccines take a piece of the viruses RNA that codes for a portion of the spike protein used to enter your cells. Your sales then make copies of that portion of the spike protein (no active virus) and that is displayed on the surface of your cells. Immune cells then come by and read that and begin making antibodies. That's it.

Nice take. I've stopped trying to explain all this beyond some form of "That's not how this works". A new piece of nonsense is created on Facebook about every 4 minutes. It's impossible to keep up with all of it.

Dude: "I don't trust the TDAP vaccine. Can't be good for them to put so much rust in your heart."

(Explains how TDAP shots work)

Dude: "More people voted in Georgia than their entire population"

(Explains how Georgia is also a country that only had 4m people)

Dude: "The Earth is flat because there are no non-stop long-haul flights between any cities in the southern hemisphere"

(...No)

(11-16-2020 07:59 AM)CoastalJuan Wrote:  

(11-16-2020 07:57 AM)TIGERCITY Wrote:  And here's the press release of Moderna's phase 3 interim results. Estimated "point efficacy" of 94.5. There were 95 cases of covid-19 in the study. 90 were in the placebo arm 5 in the vaccinated arm. 11 of the cases were "severe" *all* in the placebo arm.

https://investors.modernatx.com/news-rel...y-efficacy

Boom! We're the CRO on that one.

Two shots required?

Both Moderna's and Pfizer's vaccines required two shots. Expect to have a combined 60 million doses in December. I don't know if that means 30 or 60 million can be vaccinated. One good thing about the Moderna vaccine - it can be transported and stored at 20 degrees Fahrenheit. Now waiting on the results for Oxford:-)

(11-16-2020 09:55 AM)TIGERCITY Wrote:  Both Moderna's and Pfizer's vaccines required two shots. Expect to have a combined 60 million doses in December. I don't know if that means 30 or 60 million can be vaccinated. One good thing about the Moderna vaccine - it can be transported and stored at 20 degrees Fahrenheit. Now waiting on the results for Oxford:-)

Az is pretty far along, despite the early pauses in a few countries.


Sent from my iPhone using Tapatalk

Pfizer has completed its trial. 170 infections with 162 in the placebo arm. 95% effective and 94% effective in those over 65. To put things in perspective smallpox was eradicated with a vaccine that was 90% effective:-)

https://investors.pfizer.com/investor-ne...fault.aspx

(11-18-2020 08:17 AM)TIGERCITY Wrote:  Pfizer has completed its trial. 170 infections with 162 in the placebo arm. 95% effective and 94% effective in those over 65. To put things in perspective smallpox was eradicated with a vaccine that was 90% effective:-)

https://investors.pfizer.com/investor-ne...fault.aspx

They plan to file for emergency use authorization “within days.”

(11-18-2020 09:11 AM)Tiger1983 Wrote:  

(11-18-2020 08:17 AM)TIGERCITY Wrote:  Pfizer has completed its trial. 170 infections with 162 in the placebo arm. 95% effective and 94% effective in those over 65. To put things in perspective smallpox was eradicated with a vaccine that was 90% effective:-)

https://investors.pfizer.com/investor-ne...fault.aspx

They plan to file for emergency use authorization “within days.”

With Pfizer and Moderna looking effective, and Az close to the finish line, there should be enough manufacturing power between them to cover global demand next year. Pretty huge.

(11-18-2020 09:16 AM)CoastalJuan Wrote:  

(11-18-2020 09:11 AM)Tiger1983 Wrote:  

(11-18-2020 08:17 AM)TIGERCITY Wrote:  Pfizer has completed its trial. 170 infections with 162 in the placebo arm. 95% effective and 94% effective in those over 65. To put things in perspective smallpox was eradicated with a vaccine that was 90% effective:-)

https://investors.pfizer.com/investor-ne...fault.aspx

They plan to file for emergency use authorization “within days.”

With Pfizer and Moderna looking effective, and Az close to the finish line, there should be enough manufacturing power between them to cover global demand next year. Pretty huge.

If allowed by the FDA, the shot should go into distribution by year's end.
https://www.wsj.com/articles/pfizers-cov..._lead_pos1

Huge news...but the whole mRNA development process still has some of my colleagues in the Bioengineering Department at my institution a bit worried. The activation process for the vaccine is SO different than traditional vaccines that we really don't know what the potential impact down the road could be on our own RNA production. It is used sparingly in cancer trials and there don't seem to be significant issues, but the fact that we are literally giving instructions and material to produce the virus inside our bodies, rather than traditional vaccines which give our bodies deactivated molecular viral material to fight off is troublesome if there is no way to then limit said production.

If there do not appear to be any adverse reactions, then this could be one of the biggest breakthroughs in infectious disease prevention since penicillin moving forward into the next scientific age, we're talking about all viruses that currently exist.

Maybe talking out of my ass here since I have no idea what infrastructure or expertise are required to produce these 95% effective vaccines -- but if possible, I would like to see the president use his natural emergency powers and require Pfizer, Madonna, or any other highly effective vaccine that comes up be produced by all other companies that can effectively do it. Give them a cut. Or use the second stimulus money they're talking about and give interested parties a cut there. Get rid of this thing sooner likely does more than the stimulus money ever could.

(11-18-2020 10:16 AM)TIGERCITY Wrote:  Maybe talking out of my ass here since I have no idea what infrastructure or expertise are required to produce these 95% effective vaccines -- but if possible, I would like to see the president use his natural emergency powers and require Pfizer, Madonna, or any other highly effective vaccine that comes up be produced by all other companies that can effectively do it. Give them a cut. Or use the second stimulus money they're talking about and give interested parties a cut there. Get rid of this thing sooner likely does more than the stimulus money ever could.

The Defense Production Act was already used to create more PPE for frontline Healthcare Workers, so it could be done relatively easily. Without getting too political, I just hope the current President can set aside differences and pettiness to roll that plan out immediately should the FDA approve these options. If a stimulus is passed to fund vaccine development, it should have a rider explicitly making vaccination free to all citizens.

The more interesting question is how does this vaccine get rolled out? Does it go by individuals with risk factors first, or, cynically, do you vaccinate individuals who are likely to most positively impact the economy and workforce? Given that we won't see enough vaccines produced to vaccinate the entirety of the US population until the end of next year at the earliest (and that's if we hoard the production instead of spreading things out to all proportionally), the discussion of rollout will need to be had.

(11-18-2020 10:19 AM)BearcatMan Wrote:  

(11-18-2020 10:16 AM)TIGERCITY Wrote:  Maybe talking out of my ass here since I have no idea what infrastructure or expertise are required to produce these 95% effective vaccines -- but if possible, I would like to see the president use his natural emergency powers and require Pfizer, Madonna, or any other highly effective vaccine that comes up be produced by all other companies that can effectively do it. Give them a cut. Or use the second stimulus money they're talking about and give interested parties a cut there. Get rid of this thing sooner likely does more than the stimulus money ever could.

The Defense Production Act was already used to create more PPE for frontline Healthcare Workers, so it could be done relatively easily. Without getting too political, I just hope the current President can set aside differences and pettiness to roll that plan out immediately should the FDA approve these options.

Without getting too political, I just hope all Governors set aside their animus against political opponents and stubborn pride and request the vaccine.

(11-18-2020 10:22 AM)Tiger1983 Wrote:  

(11-18-2020 10:19 AM)BearcatMan Wrote:  

(11-18-2020 10:16 AM)TIGERCITY Wrote:  Maybe talking out of my ass here since I have no idea what infrastructure or expertise are required to produce these 95% effective vaccines -- but if possible, I would like to see the president use his natural emergency powers and require Pfizer, Madonna, or any other highly effective vaccine that comes up be produced by all other companies that can effectively do it. Give them a cut. Or use the second stimulus money they're talking about and give interested parties a cut there. Get rid of this thing sooner likely does more than the stimulus money ever could.

The Defense Production Act was already used to create more PPE for frontline Healthcare Workers, so it could be done relatively easily. Without getting too political, I just hope the current President can set aside differences and pettiness to roll that plan out immediately should the FDA approve these options.

Without getting too political, I just hope all Governors set aside their animus and stubborn pride and request the vaccine.

Completely agree, this thing is WAY bigger than petty political squabbles, and anyone who uses it for personal or political gain should be ridden out of town on a pole.

(11-18-2020 09:22 AM)Tiger1983 Wrote:  

(11-18-2020 09:16 AM)CoastalJuan Wrote:  

(11-18-2020 09:11 AM)Tiger1983 Wrote:  

(11-18-2020 08:17 AM)TIGERCITY Wrote:  Pfizer has completed its trial. 170 infections with 162 in the placebo arm. 95% effective and 94% effective in those over 65. To put things in perspective smallpox was eradicated with a vaccine that was 90% effective:-)

https://investors.pfizer.com/investor-ne...fault.aspx

They plan to file for emergency use authorization “within days.”

With Pfizer and Moderna looking effective, and Az close to the finish line, there should be enough manufacturing power between them to cover global demand next year. Pretty huge.

If allowed by the FDA, the shot should go into distribution by year's end.
https://www.wsj.com/articles/pfizers-cov..._lead_pos1

Right, but even with three or more manufacturers producing vaccines, it will probably take a good chunk of next year to get them out to everyone. Medical/frontline workers first, then elderly/at-risk people, then everyone else. Pretty massive undertaking.

Bearcatman, first these vaccines do not "produce virus" inside your body. Second, the vaccine itself has caused no adverse reactions. In fact, the vaccine is cleared after a couple of weeks leaving only your boosted immune response. No one who knows what long-term effects some people may have to that - but they'll be long-term and no one's willing to wait for 2 years for that (although phase 4 trials will continue that long)