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New Antibiotics on the Horizon?
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miko33 Offline
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Post: #1
New Antibiotics on the Horizon?
https://www.wsj.com/articles/genetic-seq...t#cxrecs_s

We are a ways off yet, but this looks really promising! The antibiotics we currently have are becoming less effective than they were even recently. This latest fall/winter in particular, I've personally experienced and seen with others I know that had to get 2 or even 3 scripts for antibiotics (Z-Packs, Amoxicillin most commonly) to kill a sinusitis infection or other bacterial respiratory infections. It's not talked about much, but IMHO allowing disease to run rampant again like the "good old days" will retard progress and innovation - although the possible side effects would be to allow human evolution to improve our resistance to disease plus cull the world population to allow the earth to better sustain us...

Quote:In a bag of backyard dirt, scientists have discovered a powerful new group of antibiotics they say can wipe out many infections in lab and animal tests, including some microbes that are resistant to most traditional antibiotics.

Researchers at Rockefeller University in New York reported the discovery of the new antibiotics, called malacidins, on Monday in the journal Nature Microbiology.

It is the latest in a series of promising antibiotics found through innovative genetic sequencing techniques that allow researchers to screen thousands of soil bacteria that previously could not be grown or studied in the laboratory. To identify the new compounds, the Rockefeller researchers sifted through genetic material culled from 1,500 soil samples.

“We extract DNA directly out of soil samples,” said biochemist Sean Brady at Rockefeller’s Laboratory for Genetically Encoded Small Molecules, a senior author on the new study. “We put it into a bug we can grow easily in the laboratory and see if it can make new molecules—the basis of new antibiotics.”

The new compounds appear to interfere with the ability of infectious bacteria to build cell walls—a function so basic to cellular life that it seems unlikely that the microbes could evolve a way to resist it. In lab tests, bacteria were exposed to the experimental antibiotics for 21 days without developing resistance, the scientists said.

So far, the new compounds also appear safe and effective in mice, but there are no plans yet to submit it for human testing. “It is early days for these compounds,” Dr. Brady said.
02-13-2018 10:06 AM
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TigerBlue4Ever Offline
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RE: New Antibiotics on the Horizon?
So, all those formative years spent playing in the dirt actually helped my immune system?
02-13-2018 10:23 AM
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EverRespect Offline
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RE: New Antibiotics on the Horizon?
(02-13-2018 10:23 AM)TigerBlue4Ever Wrote:  So, all those formative years spent playing in the dirt actually helped my immune system?

No doubt. I see it daily both at my son's school and on Facebook. The kids who are always sick and getting the flu are the ones who stay inside and whose parents have hand sanitizer stations all over the house. Hell, even my 2-year old daughter was the only kid at daycare for 2 days a couple of weeks ago because all the other kids were sick. Last time I had a viral or bacterial infection was over 10 years ago, which was the only time in my life I have had the flu. I do get seasonal allergies, which can be crippling if I wait to long to start taking claritin, but I do attribute this fact to not washing my hands and not keeping an immaculate house (3 kids and both parents work... housework only gets done on weekends).
(This post was last modified: 02-13-2018 10:38 AM by EverRespect.)
02-13-2018 10:37 AM
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TigerBlue4Ever Offline
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RE: New Antibiotics on the Horizon?
(02-13-2018 10:37 AM)EverRespect Wrote:  
(02-13-2018 10:23 AM)TigerBlue4Ever Wrote:  So, all those formative years spent playing in the dirt actually helped my immune system?

No doubt. I see it daily both at my son's school and on Facebook. The kids who are always sick and getting the flu are the ones who stay inside and whose parents have hand sanitizer stations all over the house. Hell, even my 2-year old daughter was the only kid at daycare for 2 days a couple of weeks ago because all the other kids were sick. Last time I had a viral or bacterial infection was over 10 years ago, which was the only time in my life I have had the flu. I do get seasonal allergies, which can be crippling if I wait to long to start taking claritin, but I do attribute this fact to not washing my hands and not keeping an immaculate house (3 kids and both parents work... housework only gets done on weekends).

I remember those days, ugh. And then one day the rugrats grew into something resembling humans and went away. Whew.
02-13-2018 10:48 AM
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VA49er Offline
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RE: New Antibiotics on the Horizon?
(02-13-2018 10:23 AM)TigerBlue4Ever Wrote:  So, all those formative years spent playing in the dirt actually helped my immune system?

IMO, absolutely, There is a hypotheses called the Hygiene Hypothesis that states that getting dirty is actually good for you in that it builds up the immune system. Today, kids grow up to clean which is why some folks think there has been the surge in such things as deadly peanut allergies, etc. On a different, note I blame the decreased efficacy of current antibiotics on doctors since they vastly oversubscribe antibiotics. Well, that and stupid stuff like antibacterial soap. No need to ever have antibacterial soap. Regular soap does just fine. So, any new antibiotics discovered is a great thing because, IMO, the current ones aren't going to be effective much longer.
02-13-2018 12:53 PM
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hawghiggs Offline
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RE: New Antibiotics on the Horizon?
Research Microbiome.
02-13-2018 01:30 PM
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Love and Honor Offline
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Post: #7
RE: New Antibiotics on the Horizon?
This is great news, though we must be cognizant of the antibiotic overuse that's put us in the bacteria resistance situation in the first place first of all imo.
02-13-2018 07:37 PM
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