The unofficial online home for fans of the University of Cincinnati Bearcats. Part of Collegiate Sports Nation (CSN).

(04-15-2020 07:04 PM)Bear Catlett Wrote:  

(04-15-2020 06:19 PM)BearcatsUC Wrote:  

(04-15-2020 03:05 PM)Bear Catlett Wrote:  

(04-15-2020 02:53 PM)BearcatsUC Wrote:  

(04-15-2020 02:16 PM)Bear Catlett Wrote:  I believe the question was "how are you any different".

I already told you twice: my opinion was not political. If anything, my motivation was predicting stock market movement. (The virus isn’t the big problem - its only the pin that pops the bubble.)

It’s rare that I’m so right about something, but I just happened to call this one and was rather confident about it. I was telling people to pay attention.

But I’ll be damned if I’m going to let people call this the flu, or let a politician get away with saying it’s under control, or that it’s going to
miraculously disappear, especially since he had been warned...repeatedly.

That's OK dude. Nobody else ever answers my direct questions either. Why should you be any different.

Just curious, why aren't you such a hard a$$ about the head of the health department ridiculously overstating a month ago that there were 100,000 people walking around Ohio with covid19 when actually to date there have been only about 7% of that figure? Selective hard assness?

It's OK if you duck this question too.

Only, 71,552 have been tested in Ohio to date. How can you possibly know 100,000 do not have the virus?

I watch the numbers every day:

https://www.worldometers.info/coronavirus/country/us/

I haven't been tested. You know why? Because I DONT HAVE IT.

Or are we shifting back to the asymptomatic boogeyman angle?

You know, come to think of it... how do YOU know that there aren't 100,000 martians walking around disguised as humans??? Have you tested to check???

You do not know that. Rudy Gobert didnt have it either according to him.

My wife's cousin and his husband both had it. Their symptoms while not mild were never deadly. The only reason they were allowed to be tested was because one of them is a nurse. Otherwise they'd have just stayed home and isolated. We don't have rampant, widespread testing, so a lot of people that have it aren't being tested.

(04-16-2020 08:04 AM)coachpipe Wrote:  

(04-15-2020 07:04 PM)Bear Catlett Wrote:  

(04-15-2020 06:19 PM)BearcatsUC Wrote:  

(04-15-2020 03:05 PM)Bear Catlett Wrote:  

(04-15-2020 02:53 PM)BearcatsUC Wrote:  I already told you twice: my opinion was not political. If anything, my motivation was predicting stock market movement. (The virus isn’t the big problem - its only the pin that pops the bubble.)

It’s rare that I’m so right about something, but I just happened to call this one and was rather confident about it. I was telling people to pay attention.

But I’ll be damned if I’m going to let people call this the flu, or let a politician get away with saying it’s under control, or that it’s going to
miraculously disappear, especially since he had been warned...repeatedly.

That's OK dude. Nobody else ever answers my direct questions either. Why should you be any different.

Just curious, why aren't you such a hard a$$ about the head of the health department ridiculously overstating a month ago that there were 100,000 people walking around Ohio with covid19 when actually to date there have been only about 7% of that figure? Selective hard assness?

It's OK if you duck this question too.

Only, 71,552 have been tested in Ohio to date. How can you possibly know 100,000 do not have the virus?

I watch the numbers every day:

https://www.worldometers.info/coronavirus/country/us/

I haven't been tested. You know why? Because I DONT HAVE IT.

Or are we shifting back to the asymptomatic boogeyman angle?

You know, come to think of it... how do YOU know that there aren't 100,000 martians walking around disguised as humans??? Have you tested to check???

You do not know that. Rudy Gobert didnt have it either according to him.

Which again, is addressed by isolating only those most vulnerable, not everyone.

Otherwise covid19 for those not in that category is just a risk same as the flu every year, which no one wants to get either. If you are one of the unlucky ones to get it, you get sick for a few days and you recover.

(04-16-2020 06:46 AM)converrl Wrote:  Might the chloroquine class be dual action? Both inhibiting attachment and interfering with the polymerase by raising the intracellular zinc levels? If so, it's hitting the virus on 2 fronts and could be more effective?

I would assume if they're using both chloroquine and zinc it's dual action in a sense. The separate action would likely be as a transport mechanism to bring zinc into the cell. But I think that's more of a drug "cocktail" like you were referring to previously.

Also, I don't think its accurate that chloroquine functions specifically by interfering with the polymerase. I tried finding where that comes from but only see some studies from the 60s which don't seem to be in the context of coronavirus infection.

My understanding is that it raises the endosomal pH level and prevents the glycosylation of the viral envelope, thereby preventing attachment of the virus and/or preventing activity of Proteins within the cell that would otherwise facilitate the transport of the viral RNA for translation.

Sent from my SM-G973U using Tapatalk

(04-16-2020 07:55 AM)OKIcat Wrote:  Circling back to the title of this thread, my sense as of today is yes, we will have college football this year. the NFL seems to be floating trial balloons this week about its season, with our without fans. I would expect college football to follow the NFL's lead on this. So we may see empty stadia, or greatly reduced capacity depending upon what social distancing restrictions remain in place. But if much of the country gets back to work in the May-June time frame it's reasonable to believe a modified fall practice schedule could begin in the July-August time frame.

Thank you for trying to get us back on the topic of this thread. I'm not as confident as you OKIcat that there will be College Football in 2020. I think that CFB will be back in the Spring of 2021. That's how I feel today, however we are learning more each day about this Novel Virus so CFB could return this fall.

(04-16-2020 09:45 AM)Loco Bearcat Wrote:  

(04-16-2020 07:55 AM)OKIcat Wrote:  Circling back to the title of this thread, my sense as of today is yes, we will have college football this year. the NFL seems to be floating trial balloons this week about its season, with our without fans. I would expect college football to follow the NFL's lead on this. So we may see empty stadia, or greatly reduced capacity depending upon what social distancing restrictions remain in place. But if much of the country gets back to work in the May-June time frame it's reasonable to believe a modified fall practice schedule could begin in the July-August time frame.

Thank you for trying to get us back on the topic of this thread. I'm not as confident as you OKIcat that there will be College Football in 2020. I think that CFB will be back in the Spring of 2021. That's how I feel today, however we are learning more each day about this Novel Virus so CFB could return this fall.

I am leaning towards it being back this fall, but without fans (or at least a limited number that will be strategically placed in the stadium so they are at a certain distance from one another). The problem with this will be a big loss on ticket revenue, but TV ratings will be through the roof.

(04-16-2020 09:45 AM)Loco Bearcat Wrote:  Thank you for trying to get us back on the topic of this thread. I'm not as confident as you OKIcat that there will be College Football in 2020. I think that CFB will be back in the Spring of 2021. That's how I feel today, however we are learning more each day about this Novel Virus so CFB could return this fall.

I was watching Get Up today and they were discussing the possibility of spring football. Booger basically said it was a horrible idea and I am in complete agreement. Even if you limit the season to conference only and playoffs you're looking at 10-12 games. Then you're going to turn around in 2-3 months and ask them to come back and play the normal 13-15 games in the fall so potentially almost 30 games in one calendar year? No way. Not fair to anyone and particularly if I'm a sure fire NFL prospect there's no way I'd take that kind of risk with my future.

I understand that football is the funding mechanism for college sports but you can't have these amateurs taking these kinds of risks to fund non revenue sports.

(04-16-2020 10:02 AM)RealDeal Wrote:  

(04-16-2020 09:45 AM)Loco Bearcat Wrote:  Thank you for trying to get us back on the topic of this thread. I'm not as confident as you OKIcat that there will be College Football in 2020. I think that CFB will be back in the Spring of 2021. That's how I feel today, however we are learning more each day about this Novel Virus so CFB could return this fall.

I was watching Get Up today and they were discussing the possibility of spring football. Booger basically said it was a horrible idea and I am in complete agreement. Even if you limit the season to conference only and playoffs you're looking at 10-12 games. Then you're going to turn around in 2-3 months and ask them to come back and play the normal 13-15 games in the fall so potentially almost 30 games in one calendar year? No way. Not fair to anyone and particularly if I'm a sure fire NFL prospect there's no way I'd take that kind of risk with my future.

I understand that football is the funding mechanism for college sports but you can't have these amateurs taking these kinds of risks to fund non revenue sports.

The turnaround is something I first thought of as well. Consider this: if you tear your ACL playing in Spring of 2021, a returning player will miss the fall season as well. No way they can recover that quickly.

(04-16-2020 08:48 AM)Cataclysmo Wrote:  

(04-16-2020 06:46 AM)converrl Wrote:  Might the chloroquine class be dual action? Both inhibiting attachment and interfering with the polymerase by raising the intracellular zinc levels? If so, it's hitting the virus on 2 fronts and could be more effective?

I would assume if they're using both chloroquine and zinc it's dual action in a sense. The separate action would likely be as a transport mechanism to bring zinc into the cell. But I think that's more of a drug "cocktail" like you were referring to previously.

Also, I don't think its accurate that chloroquine functions specifically by interfering with the polymerase. I tried finding where that comes from but only see some studies from the 60s which don't seem to be in the context of coronavirus infection.

My understanding is that it raises the endosomal pH level and prevents the glycosylation of the viral envelope, thereby preventing attachment of the virus and/or preventing activity of Proteins within the cell that would otherwise facilitate the transport of the viral RNA for translation.

Sent from my SM-G973U using Tapatalk

Check my links at the bottom of the original post and the YouTube bit from the CDC.

There damn well better be football. If it’s in an empty stadium fine, but enough is enough. We need to live our lives and get back to normal. 20 million and counting have just had their lives ruined by unemployment. At some point very soon it’s time to move forward with life. And I care for my two at risk parents in my house. I get the risk and how bad it is. But it’s bigger than me or them. We can’t wreck the lives of 350 million people to protect 200,000. Not over the long term.

Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

(04-16-2020 08:04 AM)coachpipe Wrote:  

(04-15-2020 07:04 PM)Bear Catlett Wrote:  

(04-15-2020 06:19 PM)BearcatsUC Wrote:  

(04-15-2020 03:05 PM)Bear Catlett Wrote:  

(04-15-2020 02:53 PM)BearcatsUC Wrote:  I already told you twice: my opinion was not political. If anything, my motivation was predicting stock market movement. (The virus isn’t the big problem - its only the pin that pops the bubble.)

It’s rare that I’m so right about something, but I just happened to call this one and was rather confident about it. I was telling people to pay attention.

But I’ll be damned if I’m going to let people call this the flu, or let a politician get away with saying it’s under control, or that it’s going to
miraculously disappear, especially since he had been warned...repeatedly.

That's OK dude. Nobody else ever answers my direct questions either. Why should you be any different.

Just curious, why aren't you such a hard a$$ about the head of the health department ridiculously overstating a month ago that there were 100,000 people walking around Ohio with covid19 when actually to date there have been only about 7% of that figure? Selective hard assness?

It's OK if you duck this question too.

Only, 71,552 have been tested in Ohio to date. How can you possibly know 100,000 do not have the virus?

I watch the numbers every day:

https://www.worldometers.info/coronavirus/country/us/

I haven't been tested. You know why? Because I DONT HAVE IT.

Or are we shifting back to the asymptomatic boogeyman angle?

You know, come to think of it... how do YOU know that there aren't 100,000 martians walking around disguised as humans??? Have you tested to check???

You do not know that. Rudy Gobert didnt have it either according to him.

He is a "Goober"

(04-16-2020 04:35 PM)Dannyboy Wrote:  There damn well better be football. If it’s in an empty stadium fine, but enough is enough. We need to live our lives and get back to normal. 20 million and counting have just had their lives ruined by unemployment. At some point very soon it’s time to move forward with life. And I care for my two at risk parents in my house. I get the risk and how bad it is. But it’s bigger than me or them. We can’t wreck the lives of 350 million people to protect 200,000. Not over the long term.

Absolutely. The media also has to get over this idea that Fauci is President of the United States.

(04-16-2020 05:07 PM)Dont tase me bro Wrote:  Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

Need fans in stands.

Need test certificate to enter.
Must wear masks.
Check temps upon entering.

There may not be a vaccine, ever. There is no HIV vaccine. Controlled by therapeutics and mitigation.

(04-16-2020 04:35 PM)Dannyboy Wrote:  There damn well better be football. If it’s in an empty stadium fine, but enough is enough. We need to live our lives and get back to normal. 20 million and counting have just had their lives ruined by unemployment. At some point very soon it’s time to move forward with life. And I care for my two at risk parents in my house. I get the risk and how bad it is. But it’s bigger than me or them. We can’t wreck the lives of 350 million people to protect 200,000. Not over the long term.

Where are the "bodies in the streets" crowd to correct Dannyboy of his...

[INHALE]

... "moronic, baseless, nauseating, strawman, lost in the trees, headslappingly silly"...

position?

PS: By the way, you're exactly right Dannyboy.

(04-17-2020 09:26 AM)Bear Catlett Wrote:  

(04-16-2020 04:35 PM)Dannyboy Wrote:  There damn well better be football. If it’s in an empty stadium fine, but enough is enough. We need to live our lives and get back to normal. 20 million and counting have just had their lives ruined by unemployment. At some point very soon it’s time to move forward with life. And I care for my two at risk parents in my house. I get the risk and how bad it is. But it’s bigger than me or them. We can’t wreck the lives of 350 million people to protect 200,000. Not over the long term.

Where are the "bodies in the streets" crowd to correct Dannyboy of his...

[INHALE]

... "moronic, baseless, nauseating, strawman, lost in the trees, headslappingly silly"...

position?

PS: By the way, you're exactly right Dannyboy.

Sometimes the needs of the few out weigh the needs of the many.

(04-17-2020 07:40 AM)doss2 Wrote:  

(04-16-2020 05:07 PM)Dont tase me bro Wrote:  Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

Need fans in stands.

Need test certificate to enter.
Must wear masks.
Check temps upon entering.

There may not be a vaccine, ever. There is no HIV vaccine. Controlled by therapeutics and mitigation.

Got to have isolation police just to make sure there is social distancing in the queue lines going on for blocks outside of the stadium. Show up 3 hrs early...

I don’t see it happening like that. If we can get through these phases efficiently enough through the summer, I see it starting up like before. Just maybe some people don’t come because they are scared. Maybe some others are wearing masks. And their should be better sanitation in restrooms and areas of contact.

If cases rebound in the meantime... we take a step back and maybe they do it without fans?

I am not hopeful about a vaccine. I am even less hopeful about an effective vaccine. I guess it depends on the mutation rate of the virus.

(04-17-2020 07:40 AM)doss2 Wrote:  

(04-16-2020 05:07 PM)Dont tase me bro Wrote:  Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

Need fans in stands.

Need test certificate to enter.
Must wear masks.
Check temps upon entering.

There may not be a vaccine, ever. There is no HIV vaccine. Controlled by therapeutics and mitigation.

HIV is not a good example.

Vaccines protect against disease, not infection
HIV is an infection until it progresses to stage 3, or AIDS. With most infections, vaccines buy the body more time to clear the infection on its own before disease occurs.

However, HIV has a long dormant period before it progresses to AIDS. During this period, the virus hides itself in the DNA of the person with the virus. The body can’t find and destroy all of the hidden copies of the virus to cure itself. So, a vaccine to buy more time won’t work with HIV.

Most vaccines protect against viruses that enter the body through the respiratory or gastrointestinal systems
More viruses enter the body in these two ways, so we have more experience addressing them. But HIV enters the body most often through genital surfaces or the blood. We have less experience protecting against viruses that enter the body in those ways.

I am optimistic about a vaccine.

The first case of H1N1 in the US were reported on April 15 2009. On December 18, 2009 the first 100 million doses of 2009 H1N1 vaccine were available for ordering.

https://www.healthline.com/health/hiv-ai...#obstacles

https://www.cdc.gov/flu/pandemic-resourc...eline.html

(04-17-2020 12:36 PM)Cat-Man Wrote:  

(04-17-2020 07:40 AM)doss2 Wrote:  

(04-16-2020 05:07 PM)Dont tase me bro Wrote:  Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

Need fans in stands.

Need test certificate to enter.
Must wear masks.
Check temps upon entering.

There may not be a vaccine, ever. There is no HIV vaccine. Controlled by therapeutics and mitigation.

HIV is not a good example.

Vaccines protect against disease, not infection
HIV is an infection until it progresses to stage 3, or AIDS. With most infections, vaccines buy the body more time to clear the infection on its own before disease occurs.

However, HIV has a long dormant period before it progresses to AIDS. During this period, the virus hides itself in the DNA of the person with the virus. The body can’t find and destroy all of the hidden copies of the virus to cure itself. So, a vaccine to buy more time won’t work with HIV.

Most vaccines protect against viruses that enter the body through the respiratory or gastrointestinal systems
More viruses enter the body in these two ways, so we have more experience addressing them. But HIV enters the body most often through genital surfaces or the blood. We have less experience protecting against viruses that enter the body in those ways.

I am optimistic about a vaccine.

The first case of H1N1 in the US were reported on April 15 2009. On December 18, 2009 the first 100 million doses of 2009 H1N1 vaccine were available for ordering.

https://www.healthline.com/health/hiv-ai...#obstacles

https://www.cdc.gov/flu/pandemic-resourc...eline.html

Vaccines DO protect against disease by preventing infection..they don't significantly help AFTER infection.

AIDS is not a good example because HIV attacks the immune system itself by converting helper T cells into virus factories that also become suicide pills for the rest of the immune system....this happens because of the expression of a membrane protein on the surface of the T helper that causes cell death when other lymphocytes come into contact with it. So HIV is unique in many aspects..

That said, there is ample evidence that those resistant to AIDS have mutations that were selected for in the CD4 protein (the one that HIV uses to invade helper T cells) during the black plague that inhibit the virus from invading...so these people can carry the virus and infect others, yet not show symptoms of AIDS...this is different from the immunity that is mediated through lymphocyte activity--but it protects those individuals from disease nonetheless.

References below:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174721/

https://www.nature.com/news/2005/050307/...07-15.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552859/

Your one-stop shop for all things related to molecular biology.

(04-17-2020 12:36 PM)Cat-Man Wrote:  

(04-17-2020 07:40 AM)doss2 Wrote:  

(04-16-2020 05:07 PM)Dont tase me bro Wrote:  Testing will be easily attainable by then, so I think they will play. Probably play in empty stadiums until a vaccine is available.

Need fans in stands.

Need test certificate to enter.
Must wear masks.
Check temps upon entering.

There may not be a vaccine, ever. There is no HIV vaccine. Controlled by therapeutics and mitigation.

HIV is not a good example.

Vaccines protect against disease, not infection
HIV is an infection until it progresses to stage 3, or AIDS. With most infections, vaccines buy the body more time to clear the infection on its own before disease occurs.

However, HIV has a long dormant period before it progresses to AIDS. During this period, the virus hides itself in the DNA of the person with the virus. The body can’t find and destroy all of the hidden copies of the virus to cure itself. So, a vaccine to buy more time won’t work with HIV.

Most vaccines protect against viruses that enter the body through the respiratory or gastrointestinal systems
More viruses enter the body in these two ways, so we have more experience addressing them. But HIV enters the body most often through genital surfaces or the blood. We have less experience protecting against viruses that enter the body in those ways.

I am optimistic about a vaccine.

The first case of H1N1 in the US were reported on April 15 2009. On December 18, 2009 the first 100 million doses of 2009 H1N1 vaccine were available for ordering.

https://www.healthline.com/health/hiv-ai...#obstacles

https://www.cdc.gov/flu/pandemic-resourc...eline.html

I remember it being sooner than that.

I know for a fact that I took my kids to get h1n1 vaccines in October.

They then recommended a booster so I took them for a second round in early December.

I remember this all so well because I took them for that second shot the night before what would turn out to be the legendary Pike-to-Binns UC-Pitt game.